ALSA-Initiated Scientific Research

This aggressive, ALS cure-directed research effort, launched in May 2000 by The ALS Association, seeks answers to key questions that must be addressed in order for better treatments and ultimately a cure for ALS to be found. This research effort complements and works in tandem with The ALS Association's Investigator-Initiated research program.

Focus of these projects includes, but is not limited to the following areas of promise:

 

View ALSA's
Research Portfolio

 

  • Human genetics - Identifying new genes involved in familial ALS
  • Genomics - Using information from the DNA sequence of the human genome to aid in genetic studies, and to search for the expression of genes associated with the disease
  • Animal Models: Transgenic mice, transgenic rats and Drosophila (fruit flies)
  • Assay development and high throughput drug screening
  • Stem cell research as potential for replacing dying neurons
  • Providing important trophic factors to dying cells and Gene Therapy and Diagnostic Biomarkers

Studies Initiated in 2005

Function of in vitro produced human motor neurons
ALS model development sensitized screens for genetic modifiers of ALS in mice
Combined delivery of growth factors and astrocytes as a potential treatment for ALS
Suppression of SOD1 as a therapy for familial ALS

Studies Initiated in 2004

ALS Model Development: Sensitized Screens for Genetic Modifiers of ALS in Mice
Generation of Transgenic Zebrafish Carrying Mutations in the Zebrafish SOD1 Gene
Long-term Toxicity and Expression of CERE-130 (AAV-IGF-1) Following Intramuscular Delivery in Rodents
Studies of Fv Single Chain Antibodies and Peptides in FALS
C. elegans Model System for Expression of Mutant SOD1 (Renewal)
NOGO and NOGO Receptor in Transgenic ALS (Renewal)
Implantation of HB9 GFP Genetically Engineered Mouse Embryonic Stem (ES) Cells to Restore Function in a Rat Model of ALS (Renewal)
Identification of Diagnostic Biomarkers and Therapeutic Targets for ALS
Purification and Transplantation of Human Stem Cell Derived Motorneurons
RNAi-Based Approach to Understanding and Treatment of ALS
Targets for ALS
Treatment of Familial Amyotrophic Lateral Sclerosis
Screens for ALS Therapeutics


ALS Research Overview
Read ALSA's White Paper on the State of ALS Research.
Meet ALSA's Science
Director & VP
Read the interview with ALSA's Science Director Lucie Bruijn, PhD.
ALSOD Database
Visit the online database for ALS/SOD1 genetic mutations at http://www.alsod.org/